Adding a certain compound to certain chemical reactions, such as: 324-03-8, name is 6-Fluoroindoline-2,3-dione, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 324-03-8, Product Details of 324-03-8
6-Fluoro-l-isopropyl-lH-indole-2,3-dione E-1.2′”” To a stirred solution of 6-Fluoro-lH-indole-2,3-dione E-1.2″”” (55.0 g; 333.1 mmol) in DMF (550 ml) is added K2C03 (55.2 g; 399.7 mmol) and 2-Iodo- propane (73.6 g; 433.0 mmol) at 25C. The reaction mixture is stirred at 25C for 16 h. Then the mixture is diluted with water and extracted with ethyl acetate. The organic layer was concentrated under reduced pressure to obtain crude compound. The crude was purified by column chromatography using silicagel (230-400 muMu) with eluting mixture of ethyl acetate and hexane. Yield: 51% (35.0 g; 169.0 mmol) HPLC-MS: (M+H)+ = 208; tRet = 2.02 min; method R D-FA-4.5-MIN
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 6-Fluoroindoline-2,3-dione, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; ENGELHARDT, Harald; WO2015/169962; (2015); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem