Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 143262-20-8, name is 1-(tert-Butoxycarbonyl)indoline-7-carboxylic acid, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of 1-(tert-Butoxycarbonyl)indoline-7-carboxylic acid
(1) 7-Indolinecarboxamide To a mixture of 1-(tert-butoxycarbonyl)-7-indolinecarboxylic acid (3.67 g, 13.9 mmol), chloroform (30 mL) and a drop of dimethyl formamide was added dropwise with stirring oxalyl chloride (5.5 mL, 63.0 mmol) over a period of 5 minutes at room temperature. After the addition, the reaction mixture was warmed to 60 C., and stirred at 60 C. for 2 hours. The reaction mixture was concentrated under reduced pressure, and thereto was added toluene (about 100 mL), and the mixture was further concentrated under reduced pressure. To the residue was added tetrahydrofuran (80 mL), and thereto was added with stirring a 29% aqueous ammonia (55 mL) with stirring under ice-cooling. The mixture was warmed to room temperature and stirred overnight. Water was added to the reaction mixture, and the mixture was extracted with chloroform. The organic layer was washed with a saturated brine, dried over anhydrous magnesium sulfate, filtered, and concentrated. The resulting residue was purified by silica gel column chromatography (SiO2, hexane:ethyl acetate=1:2, and then ethyl acetate) to give 7-indolinecarboxamide (2.02 g, yield: 90%). 1H NMR (DMSO-d6) 67; 7.62 (br, 1H), 7.36 (d, 1H, J=8.1 Hz), 7.08 (d, 1H, J=7.0 Hz), 7.00 (br, 1H), 6.61 (s, 1H), 6.46-6.41 (m, 1H), 3.52 (t, 2H, J=8.5 Hz), 2.90 (t, 2H, J=8.5 Hz)
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 143262-20-8.
Reference:
Patent; Masumoto, Shuji; Kitano, Masahumi; Ohashi, Naohito; US2003/105118; (2003); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem