Application of 1504-06-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1504-06-9, name is 3-Methyloxindole belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below.
To a Schlenk bottle, add the 2-indolinone compound (29.4 mg, 0.2 mmol) represented by Formula 1a,Copper nitrate (56.1 mg, 0.3 mmol), potassium persulfate (K2S2O8, 81.0 mg, 0.3 mmol) and ethyl acetate (2 mL) shown in formula 2a,Then, the reactor was stirred under the air atmosphere at 25 C.The reaction progress was monitored by TLC until the raw materials disappeared (reaction time was 2h). After the reaction was completed,Ethyl acetate was further added to the reaction solution, the solid residue was removed by filtration, and the solvent was concentrated under reduced pressure.The target product I-1 (90% yield) can be obtained;
The synthetic route of 3-Methyloxindole has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Yangtze Normal University; Wu Yan; Chen Jinyang; Liu Jialing; Zhong Chuntao; (9 pag.)CN110590639; (2019); A;,
Indoline – Wikipedia,
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