Application of 7477-63-6, A common heterocyclic compound, 7477-63-6, name is 7-Chloroisatin, molecular formula is C8H4ClNO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
In a 100 mL round bottom flask, according to the feed ratio (7-chloroisatin: benzyl alcohol (1:1.5); 7-chloroisatin: malondialdehyde (1:1.2))Add 7-chloroisatin 80 mg (0.44 mmol), benzyl alcohol 71.3 mg (0.66 mmol) and malondialdehyde 38.2 mg (0.53 mmol), respectively.Add a catalytic amount (0.1 times equivalent of 7-chloroisatin) of 001×7 MB, ferrocene and palladium acetate, 50 mL of solvent benzene, heat to 90 ° C, and heat the reaction for 6 hours.The reaction was monitored by thin layer chromatography. After the reaction was completed, the heating was stopped, the condensing device was removed, the mixed system was concentrated under reduced pressure, and purified by column chromatography.The target compound (14) was obtained by drying to give 115.8 mg (yield: 81percent).
The synthetic route of 7477-63-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Shaanxi University of Science and Technology; Liang Chengyuan; Tian Danni; Ding Shunjun; Wang Xuechuan; Dong Hao; Wang Qiang; (15 pag.)CN108395438; (2018); A;,
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