In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 496-12-8 as follows. name: Isoindoline
Example 68A 4-bromophenyl isoindoline-2-carboxylate To a solution of isoindoline (167 mg, 1.401 mmol) and DIEA (0.445 mL, 2.55 mmol) in CH2Cl2 (3 mL), was added 4-bromophenyl carbonochloridate (300 mg, 1.274 mmol). The mixture was stirred at rt for 1 h, then was quenched with water. The mixture was diluted with EtOAc (100 mL), then was washed with 1N HCl, sat Na2CO3 and brine, dried over Na2SO4, and concentrated. The crude product was purified via flash chromatography to afford 310 mg (76%) of Example 68A. MS (ESI) m/z: 318.0 (M+H)+; 1H NMR (500 MHz, CDCl3) delta 7.53-7.48 (m, 2H), 7.36-7.29 (m, 4H), 7.13-7.07 (m, 2H), 4.94 (s, 2H), 4.84 (s, 2H)
According to the analysis of related databases, 496-12-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Glunz, Peter W.; Zou, Yan; Quan, Mimi L.; US2014/206686; (2014); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem