These common heterocyclic compound, 61-70-1, name is 1-Methylindolin-2-one, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 1-Methylindolin-2-one
Step 2; Preparation of 1-methyl-5-nitro-1,3-dihydro-indol-2-one; 1-Methyl-1,3-dihydro-indol-2-one (Step 1, 2.10 g, 14.3 mmol) is added in portions to 70% nitric acid (10 ml) at -10 C. After the addition is complete, the reaction is allowed to warm to room temperature and then stirred for 5 hours. The mixture is diluted with ice water and the resulting precipitate filtered, washed with water, and dried under a vacuum to give the title compound as a brown solid. HPLC r.t. 3.97 min; MS for C9H8N2O3 m/Z 193.9(M+H)+.
The synthetic route of 1-Methylindolin-2-one has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Josyula, Vara Prasad Venkata Nagendra; Luehr, Gary; Gordeev, Mikhail; US2006/229348; (2006); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem