In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 340702-10-5 as follows. Computed Properties of C8H6FNO
[0128] Step c: To a 0 C suspension of 6-fluoroisoindoline-l-one (8.0 g, 5.3 mmol) in concentrated H2S04was added drop-wise a pre-cooled mixture of concentrated H2S04(26 mL) and nitric acid (6 mL) while keeping the reaction mixture below 5 C. After addition, the reaction mixture was slowly warmed to room temperature during overnight. Ice (50 g) was added to the mixture and the solid was collected and dried, then washed with MTBE (50 mL) and ethyl acetate (50 mL) to give the desired product as a light yellow solid (5.1 g, 50%). MS: (ES) m/z calculated for C8H6FN203[M + H]+197, found 197.
According to the analysis of related databases, 340702-10-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; CHEMOCENTRYX, INC.; CHEN, Xi; DRAGOLI, Dean, R.; FAN, Junfa; KALISIAK, Jaroslaw; LELETI, Manmohan, Reddy; MALATHONG, Viengkham; MCMAHON, Jeffrey; TANKAKA, Hiroko; YANG, Ju; YU, Chao; ZHANG, Penglie; MALI, Venkat; (104 pag.)WO2017/87610; (2017); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem