In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 2058-72-2 as follows. Formula: C9H6BrNO2
Example 12: Under nitrogen protection, copper powder (1.75 mmol) was sequentially added to a 10 ml reaction tube containing a magnet.1-methyl-5-nitroindole-2,3-dione (1.55 mmol), bromodifluoromethyl-1,3-benzoxazole (1.50 mmol),p-Toluenesulfonic acid (0.31 mmol) was added to dry NMP 4.0 ml and reacted at 80 C for 6 hours.After the reaction was stopped, the solid in the reaction mixture was filtered through a short silica gel column, and the filtrate was extracted with saturated brine and ethyl acetate.The organic layer was taken and dried over anhydrous sodium sulfate.Filter and concentrate. The crude product was separated and purified by column chromatography to give the desired product 3d, yield 82%.
According to the analysis of related databases, 2058-72-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Shanghai University; Jiang Haizhen; Zhang Tiantian; Miao Feng; Wang Dejing; Zhang Qian; Wang Wei; (21 pag.)CN108467391; (2018); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem