Application of 550-44-7, A common heterocyclic compound, 550-44-7, name is 2-Methylisoindoline-1,3-dione, molecular formula is C9H7NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a suspension of LiAlH4 (1.1403 g) in dry THF (24 ml) under argonatmosphere, a solution of MeOH (2 ml) in THF (24 ml) was added over 16 min at 0C,followed by cooling of the whole to -74C (in an acetone-dry ice bath). To thissuspension, N-methylphthalimide 13 (1.6177 g, 10.0 mmol) was added in portions at-74C, and the mixture was stirred at this temperature for 40 min. Then the mixture was stirred at 0C for 45 min. A saturated aqueous solution of sodium sulfate (8 ml) wasadded, and the resultant inorganic salt was filtered by suction, and the precipitate waswashed with acetone. The combined organic layer was dried over magnesium sulfate,and the organic solvent was evaporated at 30C to give the residue 14 (yellow solid,1.1544 g, 88% yield). This intermediate is rather unstable, and it was used with furtherpurification. 1H-NMR (CDCl3): delta = 7.500 (2H, m), 7.040 (2H, s), 6.904 (2H, m), 3.987(3H, s).
The synthetic route of 550-44-7 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Kozai, Daisuke; Kabasawa, Yoji; Ebert, Maximilian; Kiyonaka, Shigeki; Firman; Otani, Yuko; Numata, Tomohiro; Takahashi, Nobuaki; Mori, Yasuo; Ohwada, Tomohiko; Molecular Pharmacology; vol. 85; 1; (2014); p. 175 – 185;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem