Reference of 100487-74-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 100487-74-9, name is 6-Chloro-5-fluoroindolin-2-one belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below.
To the mixture of 6-chloro-5-fluoro-1,3-dihydro-indol-2-one (500 mg, 2.7 mmol) and 2-(4-Chloro-2-formyl-phenoxy)-2-ethyl-butyric acid methyl ester (844 mg, 2.97 mmol) (CGENETECH) in methanol (5 mL) was added pyrrolidine (95 mg, 1.35 mmol) dropwise. The mixture was then heated at 70 C. for 1 h. After cooled to room temperature, the mixture was partitioned between EtOAc and diluted HCl. The organic phase was washed with water, brine, dried over anhydrous Na2SO4 and concentrated to give the crude product as a red-yellow solid, which was used for the next step reaction without further purification.
The synthetic route of 6-Chloro-5-fluoroindolin-2-one has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Chen, Li; Han, Xingchun; Wang, Lisha; Wang, Min; Yang, Song; Zhang, Zhuming; US2010/190814; (2010); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem