Reference of 16078-34-5, A common heterocyclic compound, 16078-34-5, name is 1-(2,3-Dihydro-1H-indol-5-yl)-ethanone, molecular formula is C10H11NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: RuCl3nH2O (0.5 mol %), HMTA-Bz (1 mol %), amine (0.25 ml)and dry toluene (1.0 ml) were placed in a Schlenk tube. The reactionmixture was stirred under open condition to nitrogen andrefluxed for 24 h. After completion of the reaction all toluene wereevaporated under vacuo, the oxidized products were isolated fromcrude mixture with the help of column chromatography using hexane/EtOAc as eluent. The formation of products was confirmed bycomparing the 1H NMR data with literature reports.
The synthetic route of 16078-34-5 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Barteja, Parul; Devi, Preeti; Kannan, Muthukumar; Muthaiah, Senthilkumar; Journal of Catalysis; vol. 386; (2020); p. 1 – 11;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem