The origin of a common compound about 6-Methoxyindoline-2,3-dione

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 6-Methoxyindoline-2,3-dione, other downstream synthetic routes, hurry up and to see.

52351-75-4, Adding a certain compound to certain chemical reactions, such as: 52351-75-4, name is 6-Methoxyindoline-2,3-dione, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 52351-75-4.

6-Methoxylisatin (6 g, 33.87 mmol), 1 -indan-ethanone (40.64 mmol), and o 85% KOH pellets (120 mmol) were dissolved in EtOH (40 mL). The reaction mixture was stirred at 800C for 24 hours. After the solvent was removed by evaporation, the residue thus obtained was dissolved in H2O (50 mL). The solution was then washed twice with Et2O (30 mL). The aqueous phase was cooled by an ice- water bath and acidified with a 37% HCl aqueous solution to pH 1. The precipitate was collected by suction filtration, washed with H2O, and dried to give compound I- 20, 2-indan-5-yl-7-methoxy-quinoline-4-carboxylic acid (9.5 g, 88%) as a solid. ESI- MS (M+H+) = 320.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 6-Methoxyindoline-2,3-dione, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; TAIGEN BIOTECHNOLOGY CO. LTD.; WO2008/95058; (2008); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem