Electric Literature of 20870-79-5, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 20870-79-5 as follows.
To 250 mL acetic acid was added 7.00 g (39.3 MMOL) 5-nitro-1, 3-dihydro-indol-2-one and 418 mg (0.393 MMOL) palladium on carbon. Exposed the reaction mixture to 40 psi H2 on parr shaker for 1.5 hours. The reaction was filtered through diatameceous earth, and the acetic acid was removed under reduced pressure. Cooled the reaction mixture to 0 C and added 10.0 mL of a 94.5 : 5: 0.5 CHC13 : CH30H: NH40H solution. The solution was loaded onto a silica gel column and purified via chromatography (97.8 : 2.0 : 0.2 CHCI3 : CH30H: NH40H) to give a white solid which was further crystallized using the eluent as the solvent to give 4.06 G (27.2 mmol, 69%) of the title compound as crystalline white needles. C8H9N20 :
According to the analysis of related databases, 20870-79-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; PFIZER PRODUCTS INC.; WO2004/56786; (2004); A2;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem