Related Products of 15362-40-0, A common heterocyclic compound, 15362-40-0, name is 1-(2,6-Dichlorophenyl)-2-indolinone, molecular formula is C14H9Cl2NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Example 4Step a) of preparation of Potassium diclofenacIn a four-necked glass flask the following ingredients were charged:1 -(2,6-dichlorophenyl)-2-indolinone g 100 (moles: 0.359) – Water cc 435- Sodium hydrosulfite g 4- Potassium hydroxide 90 % g 33.6 (moles: 0.539)The mixture was refluxed for 8h 30 min, then cooled to 35 – 37 C. The precipitate was filtered on buchner funnel, then washed with a 1 % NaCI solution in water (cc 70) preheated to 35 C. Wet 180,2 grams of potassium diclofenac were obtained corresponding to dry 1 12,1 grams (Theor. g 120.17).
The synthetic route of 15362-40-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; COSMA S.P.A.; IBSA INSTITUT BIOCHIMIQUE S.A.; AVOGADRI, Alvaro; LUSSANA, Massimiliano; PIZZATTI, Enrica; BARETTI, Sergio; WO2010/69397; (2010); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem