Some common heterocyclic compound, 7477-63-6, name is 7-Chloroisatin, molecular formula is C8H4ClNO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of 7-Chloroisatin
7-Chloroisatin 1a (0.5 mmol, 90.6 mg), CuI (10 molpercent, 9.5 mg) was added to a 15-mL thick-walled pressure tube, 1,10-phenanthroline(10 molpercent, 9.0 mg) and ethyl isocyanoacetate 2 (0.6 mmol, 67.2 mg) were added, and 2 mL of toluene was added as the solvent The oil bath was 110 ¡ã C and the reaction was followed by TLC until the reaction was complete. After the end of the reaction, stop heating, transfer to a single mouth bottle spin, with PE: EA = 4: 1 column chromatography gave the product as a yellow solid which was identified as 7-chloro-3-methyleneindolone 3a by NMR and HRMS. The yield was 75percent.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 7477-63-6, its application will become more common.
Reference:
Patent; Qingdao University of Science and Technology; Li, Ming; Yu, Le; Wen, Lirong; (14 pag.)CN106083690; (2016); A;,
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