Reference of 954-81-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 954-81-4 name is N-(5-Bromopentyl)phthalimide, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
General procedure: To a stirred suspension of phenol (12 mmol) and K2CO3 (20 mmol) in DMF (20 mL), intermediates 2a-2e (10 mmol) were added. After stirred at room temperature for 10-12 h, the mixture was quenched with water and extracted with EtOAc for three times. The combined organic phase was dried over MgSO4, filtered and concentrated to give the crude product, which was puried by chromatography on an silica gel column (EtOAc/petroleum ether as eluent) to give the products. The preparation of compounds 3a-3e was according to the method previously described [42].
At the same time, in my other blogs, there are other synthetic methods of this type of compound, N-(5-Bromopentyl)phthalimide, and friends who are interested can also refer to it.
Reference:
Article; Shan, Wen-Jun; Huang, Ling; Zhou, Qi; Meng, Fan-Chao; Li, Xing-Shu; European Journal of Medicinal Chemistry; vol. 46; 12; (2011); p. 5885 – 5893;,
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