Application of 21857-45-4, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 21857-45-4 as follows.
7-Benzyl-4-chloro-2-methyl-5H-pyrrolo[3,2-d]pyrimidine 11 15(0.1 g, 0.39 mmol) and 5-methoxyindoline (58 mg, 0.48 mmol) were dissolved in isopropanol (15 mL) and heated at reflux for 12 h, and the solvent was evaporated in vacuo. The crude material obtained was purified by column chromatography and eluted with 1% (v/v) MeOH/CHCl3. Fractions containing the product (TLC) were pooled, and the solvent was evaporated to afford 4 (109 mg, 76%). TLC Rf 0.4 (MeOH: CHCl3; 1:20).
According to the analysis of related databases, 21857-45-4, the application of this compound in the production field has become more and more popular.
Reference:
Article; Pavana, Roheeth Kumar; Choudhary, Shruti; Bastian, Anja; Ihnat, Michael A.; Bai, Ruoli; Hamel, Ernest; Gangjee, Aleem; Bioorganic and Medicinal Chemistry; vol. 25; 2; (2017); p. 545 – 556;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem