Related Products of 100510-65-4,Some common heterocyclic compound, 100510-65-4, name is 6-Amino-3,3-dimethylindolin-2-one, molecular formula is C10H12N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
EXAMPLE A 6-Benzoylamino-2,3-dihydro-3,3-dimethyl-(1H)-indolin-2-one To a suspension of 5.28 g. (0.03 mole) 6-amino2,3-dihydro-3,3-dimethyl-(1H)-indolin-2-one and 4.6 ml. triethylamine in 50 ml. anhydrous dichloromethane is added dropwise at 0 C., within the course of 15 minutes, 4.36 g. (0.031 mole) benzoyl chloride, followed by stirring for 1 hour at ambient temperature. The reaction mixture is then mixed with 200 ml. ice water and the precipitate is filtered off with suction, washed with water and recrystallized from methanol. Yield 7.8 g. (93% of theory); m.p. 251-254 C.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 6-Amino-3,3-dimethylindolin-2-one, its application will become more common.
Reference:
Patent; Boehringer Mannheim GmbH; US4985448; (1991); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem