Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 496-12-8, name is Isoindoline, A new synthetic method of this compound is introduced below., COA of Formula: C8H9N
To ketone 24 (43 mg, 0.15 mmol) in anhydrous THF/CH2Cl2 (1.5 ml/1.5 mL) is added isoindoline (25 muL, 0.22 mmol) and glacial acidic acid (3 muL) and triacetoxyl sodium borohydride (98 mg, 0.44 mmol). The mixture is stirred for 2 h and, quenched with saturated sodium bicarbonate, and extracted with CH2Cl2. The organic phase is dried, rotavaped, and was subjected to HPLC purification (aetonitrile-water-0.1% TFA) to give the title compound as a TFA salt (67 mg, 89%).1H-NMR (400 MHz, CDCl3) delta=2.2 (4H, m), 2.3 (3H, s), 2.4 (3H, s), 3.2 (2H, m), 3.6 (1H, m), 3.8 (2H, m), 4.5 (4H, bs), 5.1 (2H, bs), 7.3 (9H, m).HR MS (m/z, MH+) meas. 399.2547.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Novartis AG; US2010/41663; (2010); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem