Application of 6-Nitroindoline

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 6-Nitroindoline, other downstream synthetic routes, hurry up and to see.

19727-83-4, A common compound: 19727-83-4, name is 6-Nitroindoline, belongs to indolines-derivatives compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below.

To a solution of nitroindoline(0.54g, 3.29mmol) in THF (7mL) was added di-tert-butyl dicarbonate (0.72g, 3.29mmol) and DMAP (0.44g, 3.62mmol) . The resulting mixture was stirred overnight at rt. The reaction was then diluted with EtOAc and washed with IN HCl. The organic layer was neutralized with sat. NaHCO3, washed with sat. NaCl (2x), dried over Na2SO4, filtered, and concentrated in vacuo to yield tert-butyl 6-nitroindoline-l-carboxylate as a yellow solid. MS (ES+): m/z EPO 265 [M+l]. 1H NMR (d6-DMSO, 400MHz): delta 1.49 (s, 9H), 3.16 (t, J= 8.8 Hz, 2H), 3.98 (t, J= 8.8 Hz, 2H), 7.42 (d, J= 8.4 Hz, IH), 7.81 (dd, J= 8.4 Hz, 2.0 Hz, IH), 8.41 (s, IH).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 6-Nitroindoline, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; OSI PHARMACEUTICALS, INC.; WO2006/34111; (2006); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem