Synthetic Route of 7477-63-6, A common heterocyclic compound, 7477-63-6, name is 7-Chloroisatin, molecular formula is C8H4ClNO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: Amixture of isatin (1.0 mmol), malononitrile or its derivative (1.0mmol) and Et3N (1.0 mmol) in 3.0 mL ethanol were stirred at roomtemperature for half an hour. Then a solution of hydrazine hydrate (1.1 mmol)and dialkyl acetylenedicarboxylate (1.1 mmol) in 2.0 mL ethanol was added toit. The whole solution was stirred at room temperature for stipulated time asindicated in Table 2. The progress of the reaction was monitored by TLC. Aftercompletion of the reaction, the resulting precipitates were collected by filtration and the crudeproduct was recrystallized from the mixture of methanol and acetonitrile (7:3). In some cases the crude product were purified by columnchromatography using silica gel (60-120 mesh) and 50percent ethyl acetate in hexaneas eluent.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Pal, Suman; Khan, Md. Nasim; Karamthulla, Shaik; Abbas, Sk Jahir; Choudhury, Lokman H.; Tetrahedron Letters; vol. 54; 40; (2013); p. 5434 – 5440;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem