Related Products of 3339-73-9,Some common heterocyclic compound, 3339-73-9, name is 3-(1,3-Dioxoisoindolin-2-yl)propanoic acid, molecular formula is C11H9NO4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
An aqueous solution of sodium hydroxide (9.1mmol in 50ml) was added dropwise to a well-stirred solution of N-phthaloyl-beta-alanine (9.1mmol) in ethanol (40ml) at room temperature. The solution was stirred for next 2h and then 4.5mmol of magnesium acetate [Mg(CH3COO)2] were added. The solution was heated to 80C and stirred at this temperature for 2h. The hot solution was filtered and set aside for crystallization. After four weeks, ?2g (41% yield) of colorless single crystals were obtained. The synthesis protocol of MgNPA is shown in Scheme 1(b).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-(1,3-Dioxoisoindolin-2-yl)propanoic acid, its application will become more common.
Reference:
Article; Nadeem, Muhammad; Bhatti, Moazzam H.; Sayin, Koray; Yunus, Uzma; Mehmood, Mazhar; Mehboob, Shoaib; Floerke, Ulrich; Journal of Molecular Structure; vol. 1170; (2018); p. 1 – 8;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem