Adding a certain compound to certain chemical reactions, such as: 350797-56-7, name is 3-(7-Cyano-5-(2-nitropropyl)indolin-1-yl)propyl benzoate, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 350797-56-7, HPLC of Formula: C22H23N3O4
Procedure-2: To a stirring solution of 3-(7-Cyano-5-(2-nitropropyl)-indolin-l-yl)- propyl benzoate of Formula XII (10 g, 25.4mmol) in methanol (50 ml) was added con. HC1 (10 ml) followed by Zn (3.35 g, 50.08mmol). The mixture was heated to 60-65 C for 20 h. After completion of the reaction, the mixture was filtered and the residue was washed with Methanol (5 ml). The filtrate was concentrated under vacuum and the residue was dissolved in water and washed with isopropyl ether (2×20 ml). The MDC (80 ml) was added to the aqueous layer and basified the mixture by adding aqueous 20% NaOH solution. The obtained solid slurry mass was filtered and both the layers were separated from the filtrate. The organic layer was washed twice with water (2 x 100 ml) and concentrated under vacuum to get 8.5 g of 3-(5-(2-aminopropyl)-7- cyanoindolin-l-yl)propyl benzoate of Formula XII as a thick mass (HPLC purity is -abo-ve-95-%).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-(7-Cyano-5-(2-nitropropyl)indolin-1-yl)propyl benzoate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; PANACEA BIOTEC LTD; JAIN, Rajesh; RAO, Jagadeeshwar R; RAO, Siripragada Mahender; WO2012/131710; (2012); A2;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem