Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 20870-79-5, name is 5-Nitroindolin-2-one, A new synthetic method of this compound is introduced below., Quality Control of 5-Nitroindolin-2-one
Step-b: tert-butyl 5-nitro-2-oxoindoline-l-carboxylate: Di-tert-butyl dicarbonate (4.63 g, 21.2 mmol) and sodium hydrogen carbonate (10.7 g, 127 mmol) were added to a stirred solution of 5-nitroindoIin-2-one (3.0 g, 14.2 mmol) in THF (150 mL) and the mixture was heated to 60C. After 3h, the reaction mixture was cooled, filtered and the filtrate was concentrated under reduced pressure. The obtained crude was purified by chromatography by using silica gel using a mixture of 10% ethyl acetate/hexane as an eluent to get the desired compound as a white solid as (2.3 g, 51%). 1H-NMR (300 MHz, DMSO-i/6): delta 8.3 (d, 1H), 8.2 (s, 1H), 7.9 (d, 2H), 3.8 (s, 2H), 1.5 (s, 9H).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; ORION CORPORATION; UJJINAMATADA, Ravi Kotrabasaiah; HOSAHALLI, Subramanya; SAMAJDAR, Susanta; ABBINENI, Chandrasekhar; WO2015/92118; (2015); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem