Electric Literature of 6941-75-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 6941-75-9, name is 5-Bromoisoindoline-1,3-dione, This compound has unique chemical properties. The synthetic route is as follows.
To a solution of 5-bromoisoindoline- 1, 3-dione (3) (25 g, 110.6 mmol, 1.0 equiv) in THF (60 mL) was added BF3 (30 g, 442.4 mmol, 4.0 equiv) dropwise at 0 C. The mixture was stirred at 0 C for 1.5 h and BH3 (650 ml, 1.0 M, 6.0 equiv) was added dropwise at 0 C. Then the mixture was heated to 80C for 20 h and quenched by addition of methanol (100 mL) dropwise for 1 h at 0C. The mixture was concentrated to give a crude product of 5-bromoisoindoline (4) (22 g), which was used for next step directly.
The chemical industry reduces the impact on the environment during synthesis 5-Bromoisoindoline-1,3-dione. I believe this compound will play a more active role in future production and life.
Reference:
Patent; NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING; QI, Xiangbing; LOU, Mingliang; WU, Enlong; CHEN, Peihao; WU, Qingcui; (41 pag.)WO2018/95260; (2018); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem