In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 356068-93-4, name is (Z)-5-((5-Fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below. category: indolines-derivatives
To a stirred solution of compound 109 (0.5 g, 1.67 mmol) in DMF( 40 mL) at O0C was added etaOBt (0.34 g, 2.5 mmol), triethylamine (0.94 mL, 6.68 mmol), ECDI etaC1 (0.48 g, 2.5 mmol) and compound 303 (0.44 g, 2.0 mmol) successively. The mixture was stirred overnight at room temperature, evaporated, diluted with water (50 mL), brine (50 mL) and saturated aqueous sodium bicarbonate(50 mL). The peta of solution was adjusted to 11-12 with 1OM NaOH. The mixture was
The synthetic route of 356068-93-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; CURIS, INC.; WO2008/33747; (2008); A2;,
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