Adding a certain compound to certain chemical reactions, such as: 1336963-95-1, name is 6-Bromo-7-fluoroindoline-2,3-dione, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1336963-95-1, Computed Properties of C8H3BrFNO2
In a solution of compound 2 (2.80 g, 11.48 mmol) in 50 ml of ethanol,Hydrazine hydrate (85%, 0.5 mL) was added under a nitrogen atmosphere,After refluxing for thirty minutes,There is a yellow product after precipitation by suction after drying,Was dissolved in 50 ml of ethanol,T-BuOK (4.03 g, 35.90 mmol) was added,After refluxing for 2 h, the reaction mixture was poured into water,The pH of the system was adjusted to 2 with hydrochloric acid,After extraction with ethyl acetate,Washed,Saturated salt water washing,After drying, distillation under reduced pressure.After the column by silica gelTo give the title compound 3 (1.49 g, yield 56%).
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Reference:
Patent; Peking University; Pei, Jian; Lei, Ting; Dou, Jinhu; (29 pag.)CN103804271; (2016); B;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem