Adding a certain compound to certain chemical reactions, such as: 341988-36-1, name is Methyl indoline-6-carboxylate, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 341988-36-1, Quality Control of Methyl indoline-6-carboxylate
A solution of 2,3-dihydro-1H-indole-6-carboxylic acid methyl ester (0.23 g, 1.30 mmol) in pyridine (0.60 mL) was treated with 3,5-dimethylbenzenesulfonyl chloride (0.30 g, 1.47 mmol) and stirred at room temperature for 2 hours. The mixture was diluted with 1N HCl and extracted with dichloromethane. The combined organic phases were washed with brine, dried over magnesium sulphate and evaporated. The residue was taken up in heptane/ethyl acetate 1:1 and filtered. The filtrate was pure 1-(3,5-dimethyl-benzenesulfonyl)-2,3-dihydro-1H-indole-6-carboxylic acid methyl ester, 0.41 g (92percent), MS (ISP): m/e=346.3 (M+H).
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Reference:
Patent; Ceccarelli, Simona M.; Chomienne, Odile; Mattei, Patrizio; Sander, Ulrike Obst; US2008/153805; (2008); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem