In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 923590-95-8, name is 4-Bromoisoindoline hydrochloride belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below. 923590-95-8
Step 1: preparation of benzyl 4-bromoisoindoline-2-carboxylate (compound 3a) To a solution of 4-bromoisoindoline hydrochloride (235 mg, 1.0 mmol) in THF (4 mL) was added TEA (355 mg, 0.49 mL, 3.5 mmol). The mixture was then cooled with ice-water bath. CbzCl (256 mg, 0.22 mL, 1.5 mmol) was added dropwise. The reaction mixture was stirred at rt overnight, then diluted with water (20 mL), and extracted with EtOAc (30 mL) twice. The combined organic layer was washed with brine, dried over Na2SO4 and concentrated to give a crude product which was purified by column chromatography to afford compound 3a (255 mg) as a pink solid. MS: calc’d 332&334 (MH+), measured 332&334 (MH+).
The synthetic route of 923590-95-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; F. Hoffmann-La Roche AG; The designation of the inventor has not yet been filed; (99 pag.)EP3623369; (2020); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem