Some common heterocyclic compound, 552330-86-6, name is 5-Bromoisoindolin-1-one, molecular formula is C8H6BrNO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 552330-86-6
Toa solution of6F (6 g, 28 mmol)in MeOH(IOO mL), palladium acetate (0.12g), Et3N (8.6 g, 85 mmol) and Xantphos (0.6g) were added. The reactionmixturewas stirredat 140 C under CO (3 MPa)overnight.Themixturewas cooled to room temperature and filtered.The filtrate was concentrated in vacuum to provide 6G (6 g). 1H-NMR (400 MHz, DMSO_d6): 8.82-8.84 (s,IH),8.16-8.18 (s,IH), 8.05-8.07(s, IH), 7.79-7.8l(s,IH), 4.44-4.46 (s, 2H), 3.90-3.92 (s, 3H)
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 552330-86-6, its application will become more common.
Reference:
Patent; BAIKANG (SUZHOU) CO., LTD; HAN, Jie; WO2015/81891; (2015); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem