A common compound: 496-12-8, name is Isoindoline, belongs to indolines-derivatives compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below. 496-12-8
General procedure: To a solution of compound 5 (1.0eq.) and Ia-f (1.0eq.) was added K2CO3 (2.2eq.) in anhydrous DMF at RT. After stirring for 5-7h, the reaction was diluted with water and the precipitation was filtered to afford the crude targets. Then the crude target was purified by flash column chromatography (EtOAc : PE=1 : 5) to afford the compounds 6a-f. Targets 7a-e, 8a-d and 9a-c were obtained as the procedure for 6a-f by the reaction of compound 5 witha-e, IIIa-d and IVa-c.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 496-12-8, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Wang, Apeng; Yang, Yang; Jun, Yangsheng; Wang, Bin; Lv, Kai; Liu, Mingliang; Guo, Huiyuan; Lu, Yu; Bioorganic and Medicinal Chemistry; vol. 26; 8; (2018); p. 2073 – 2084;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem