In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4702-13-0, name is N-Phthaloylglycine belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below. 4702-13-0
To a solution of phthaloylglycin (0.300 g, 1.46 mmol) in CH2Cl2 was added oxalyl chloride (1.480 g, 11.66 mmol) and DMF (0.010 g, 0.137 mmol) at 0 C. The mixture was stirred at 0 C for 30 min., then warmed to room temperature and stirred for 3 h. The solvent was removed under reduced pressure. The solid residue was dissolved in CH2Cl2 and evaporated under reduced pressure (this procedure was repeated three times). The crude product was dried under vacuum to afford a yellow sold (0.310 g, 95%). This compound was used for next reaction without further purification.1H NMR (500 MHz, CDCl3). delta 7.91 (dd, J = 5.5, 3.2 Hz, 2H), 7.79 (dd, J = 5.5, 3.1 Hz, 2H), 4.82 (s, 2H).
The synthetic route of 4702-13-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; H. LEE MOFFITT CANCER CENTER & RESEARCH INSTITUTE, INC.; BURNETTE, Pearlie; LAWRENCE, Harshani; LAWRENCE, Nicholas J.; (285 pag.)WO2017/161119; (2017); A1;,
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