In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 3416-57-7 as follows. 3416-57-7
[00653] To a mixture of 89 (4.00 g, 19.7 mmol, 1.0 eq), 4-methylbenzenesulfonic acid (1.02 g, 5.91 mmol, 0.3 eq) and ethane-1,2-diol (20 mL) in toluene (20 mL) was stirred at 110 C overnight under nitrogen. The mixture was concentrated and the residue was purified by SGC (petroleum ether / ethyl acetate, 5 / 1) to afford the desired product 90 (2.90 g, 11.7 mmol, 59.5%) as a white solid.[00654] LCMS: ESI-MS: m/z: 248.2 [M+H1 RT = 1.49 mm. (Method A)
According to the analysis of related databases, 3416-57-7, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ALPHARMAGEN, LLC; PUTMAN, David, G.; DASSE, Olivier; HOGENKAMP, Derk; (154 pag.)WO2016/144792; (2016); A1;,
Indoline – Wikipedia,
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