Adding a certain compound to certain chemical reactions, such as: 22190-33-6, name is 5-Bromoindoline, belongs to indolines-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 22190-33-6, Quality Control of 5-Bromoindoline
Step A: tert-Butyl 5-bromo-2,3-dihvdro-lH-indole-l-carboxylate To a stirred solution of 5-bromoindoline (320 mg, 1.62 mmol) in THF (8 mL) was added di-tert-butyl dicarbonate (529 mg, 2.42 mmol) and the resulting mixture was stirred at ambient temperature for 18 h. The reaction mixture was concentrated in vacuo and the residue was purified by silica gel chromatography, eluting with a gradient of hexane:EtOAc – 100:0 to 90:10, to give the title compound.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 5-Bromoindoline, and friends who are interested can also refer to it.
Reference:
Patent; MERCK SHARP & DOHME CORP.; BELL, Ian, M.; ZHAO, Lianyun; FRALEY, Mark; ZHU, Cheng; BIFTU, Tesfaye; BRNARDIC, Edward Joseph; WANG, Cheng; ZARTMAN, C. Blair; GALLICCHIO, Steven; NGUYEN, Diem; CROWLEY, Brendan; POTTEIGER, Craig; (257 pag.)WO2016/22644; (2016); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem