The chemical industry reduces the impact on the environment during synthesis 317-20-4, name is 7-Fluoroisatin, I believe this compound will play a more active role in future production and life. 317-20-4
EXAMPLES Example 1 Preparation of 7-Fluoro-1,3-dihydroindol-2-one; To a mixture of 7-fluoro-1H-indole-2,3-dione (100 g, 0.606 mol) in ethylene glycol (500 mL) was added an aqueous hydrazine solution (54% wt, 73 g, 1.21 mol) dropwise over 30 minutes. The mixture was heated to 120 C. and stirred for 6 hours. The mixture was cooled to room temperature and water (500 mL) was added. Concentrated hydrochloric acid (HCl; 60 mL) was added, the mixture was warmed to about 35 to about 40 C., and the mixture was stirred for 1 hour. The mixture was then cooled to about 0 to about 5 C. The solid compound was filtered, washed with cold water and dried at 55 C. under vacuum to give an off-white solid (76 g) in 83% yield with 96% HPLC purity.
The chemical industry reduces the impact on the environment during synthesis 317-20-4. I believe this compound will play a more active role in future production and life.
Reference:
Patent; Wyeth; US2007/27327; (2007); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem