Reference of 480-91-1, A common heterocyclic compound, 480-91-1, name is Isoindolin-1-one, molecular formula is C8H7NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A 5 mL microwave tube was cliargedwimisomdolin-l-one (0.2544 g, 1 .911 mmol), cesium caib onate ( 1.245 g.3.82 mmol) and N-memyl-2-pynOlidinone (9.55 mL) to give a colorless solution. Bmmoa etaldehyde dimethyl acetal ( 1.125 mL, 9 5 mmol) was added . The tu e was sealed, and the reaction mixture was heated in a Eiotage Creabrat 160 *C fcr 60 minutes fined hold time. The reaction mixture was partitioned between ethyl acetate and water. The organic layerwas washed with saturated aqueous sodium chloride, dried over anhydrous magnesium sulfate, filtered, and concentrated. The reaction mixture was purified b y flas h chromatography (20-70 % ethyl acetate :heptane) to provide ab lown oil (0.179 g, 42 % yield).
The synthetic route of 480-91-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ABBVIE INC.; ABBVIE PHARMACEUTICAL TRADING (SHANGHAI) CO., LTD.; FIDANZE, Steven D.; LIU, Dachun; MANTEI, Robert A.; MCDANIEL, Keith F.; PRATT, John; SHEPPARD, George S.; WANG, Le; BOGDAN, Andrew; HOLMS, James H.; DIETRICH, Justin D.; MARJANOVIC, Jasmina; HASVOLD, Lisa A.; DAI, Yujia; WO2014/139324; (2014); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem