Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 84378-94-9, name is 4-Chloro-5-fluoroindoline-2,3-dione, A new synthetic method of this compound is introduced below., Computed Properties of C8H3ClFNO2
2-amino-5-fluoro-6-chlorobenzoic acid 0.01mol joined is provided with a reflux condenser, magneton, thermometer in three-necked bottle, adding toluene 15 ml, dry SOCl 2 3 ml, reflux 1h, stopping reaction, rotary evaporation under reduced pressure to remove the solvent and redundant SOCl 2. Then added to the flask 0.01moL of 5-fluoro-4-chloro Indoloquinone (5-fluoro-6-chloro Indoloquinone) and 15 ml of dichloromethane, to continue to reflux reaction 1h, cooling to room temperature, filtered, to obtain the yellow solid, washing with methanol, dichloromethane or toluene recrystallization
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Northwest University; Huo, Baolong; Wang, Cuiling; (52 pag.)CN105330666; (2016); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem