Reference of 1127-59-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1127-59-9, name is 7-Methylindoline-2,3-dione belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below.
General procedure: To a solution of isatin 1 (1 mmol) in THF (2 mL) was added La(OTf)3 (5 mol percent). The mixture was cooled to -78 °C and stirred at this temperature for 15 min. Then the solution of 2-(trimethylsilyloxy)furan 2 (1.5 mmol) in THF (1 mL) was added dropwise. The mixture was stirred at -78 °C for 2 h. Later the mixture was brought to 20 °C and stirred for additional 0.5-1.5 h (Table 1). The reaction was monitored by TLC. After the completion of the reaction it was diluted with tetrahydrofuran (2.0 mL) and quenched with 10percent aqueous HCl (1.0 mL). The mixture was stirred for 0.25 h at room temperature, neutralized by the addition of a saturated aqueous NaHCO3 solution, and extracted with ethyl acetate (3.x.5 mL). The combined organic layer washed with brine solution, dried over Na2SO4, and concentrated under reduced pressure (rotary evaporator). The crude products were purified by silica gel column chromatography (ethyl acetate/hexanes). The inseparable diastereomers threo/erythro ratio of the product was determined by 1H NMR analysis of the crude reaction mixture.
The synthetic route of 7-Methylindoline-2,3-dione has been constantly updated, and we look forward to future research findings.
Reference:
Article; Meshram, Harshadas Mitaram; Ramesh, Palakuri; Reddy, Bandi Chennakesava; Sridhar, Balasubramanian; Yadav, Jhillu Singh; Tetrahedron; vol. 67; 17; (2011); p. 3150 – 3155;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem