Application of 141452-01-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 141452-01-9, name is Methyl indoline-5-carboxylate belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below.
Step 2: Methyl 1- (3, 4, 5-Trimethoxy-benzyl)-2, 3-DIHYDRO-LH-INDOLE-5-CARBOXYLATE (21); [0193] To a solution of 20 (300 mg, 1.69 MMOL), 3,4, 5-trimethoxybenzaldehyde (365 mg, 1.86 MMOL) and dibutyltin dichloride (51 mg, 0.17 MMOL) in THF (8 mL) was added phenylsilane (229 ss 1.86 MMOL). The mixture was stirred overnight at room temperature under nitrogen. Additional aldehyde and PHENYLSILANE were added and the stirring continued until starting material was consumed. THF was evaporated in vacuum and the residue was purified by flash chromatography (eluent 20% EtOAc in hexane). The compound was further purified by re-crystallization in a mixture EtOAc/hexane and finally by a second flash chromatography (eluent 20% EtOAc in hexane) to give the title compound 21 (428 mg, 71%) as a white SOLID. H-NMR (DMSO) 8 : 2.96 (t, J = 8.4 Hz, 2H); 3.45 (t, J = 8.7 Hz, 2H); 3.61 (s, 3H); 3.71 (s, 6H); 3.72 (s, 3H); 4.30 (s, 2H); 6.59 (s, 2H); 6.61 (d, J = 8.4 Hz, 1H), 7.54 (d, J = 1. 6 Hz, 1H); 7.63 (dd, J = 1.8, 8.4 Hz, 1H).
The synthetic route of Methyl indoline-5-carboxylate has been constantly updated, and we look forward to future research findings.
Reference:
Patent; METHYLGENE, INC.; WO2005/30704; (2005); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem