Synthetic Route of 611-09-6, These common heterocyclic compound, 611-09-6, name is 5-Nitroindoline-2,3-dione, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Weigh5-nitroindole-dione 5.00g (26.02mmol) into a 250mL round bottom flask was added150mL of cyclohexane under stirring conditions, neopentyl glycol was slowlyadded 2.98g (28.63mmol), of methylbenzenesulfonate 0.896g (5.20mmol), thenheated at reflux at 100 6h.Starting material disappeared on TLC, cooled to room temperature, suctionfiltered, washed with a saturated aqueous sodium hydrogen carbonate builders,and dried under vacuum oven to give 5-nitro-3,3-shrink glutaraldehyde newindolinone 6.63g, yield 91.6%.
Statistics shows that 5-Nitroindoline-2,3-dione is playing an increasingly important role. we look forward to future research findings about 611-09-6.
Reference:
Patent; Tianjin University of Science&Technology; Yu, peng; Liu, fengxi; sun, HUA; Teng, yuou; Guo, qiannan; Han, kailin; Li, Huan Huan; Yang, yao; song, BINBIN; (19 pag.)CN103554008; (2016); B;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem