Application of 201940-08-1, The chemical industry reduces the impact on the environment during synthesis 201940-08-1, name is tert-Butyl 5-bromoisoindoline-2-carboxylate, I believe this compound will play a more active role in future production and life.
Reference Example 17 tert-butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoindoline-2-carboxylate (0344) tert-butyl 5-bromoisoindoline-2-carboxylate (i.e., Matric Scientific, catalog 74109) (20 g, 0.0671 mol), 4,4,4?,4?,5,5,5?,5?-octamethyl-2,2?-bi(1,3,2-dioxaborolane) (17 g, 0.0671 mol), KAc (8.5 g, 0.087 mol) and PdCl2dppf (1.8 g, 0.00221 mol) in 200 mL 1,4-dioxane was heated to 80 C. overnight. The mixture was cooled, water was added, the mixture was extracted with EA, dried and concentrated. The residue was purified by chromatography on silica gel to afford the title compound. 1HNMR (300 MHz, DMSO) delta: 1.2-1.3 (s, 12H), 1.4-1.5 (s, 9H), 4.5-4.6 (s, 4H), 7.2-7.3 (m, 1H), 7.5-7.6 (M, 2H); LC-MS: m/z=246 (M+1-100)+.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, tert-Butyl 5-bromoisoindoline-2-carboxylate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Merck Sharp & Dohme Corp.; Mandal, Mihir; Tang, Haifeng; Xiao, Li; Su, Jing; Li, Guoqing; Yang, Shu-Wei; Pan, Weidong; Tang, Haiqun; DeJesus, Reynalda; Hicks, Jacqueline; Lombardo, Matthew; Chu, Hong; Hagmann, William; Pasternak, Alex; Gu, Xin; Jiang, Jinlong; Dong, Shuzhi; Ding, Fa-Xiang; London, Clare; Biswas, Dipshikha; Young, Katherine; Hunter, David N.; Zhao, Zhiqiang; Yang, Dexi; (405 pag.)US2016/333021; (2016); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem