Related Products of 65826-95-1,Some common heterocyclic compound, 65826-95-1, name is 5-Methylindoline, molecular formula is C9H11N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
250ml four-necked flask, under a nitrogen atmosphere,Add 0.01mol 3,6-dibromo-9H-carbazole, 0.03molCompound 5-methyl 2,3-dihydro-1H-indole, 0.03 mole sodium t-butoxide, 1 x 10-4 mole Pd2(dba)3, 1 x 10-4 mole tri-t-butylphosphine, 150 ml toluene, heated After refluxing for 24 hours, the sample was spotted, the reaction was complete, natural cooling, filtration, and the filtrate was rotary-steamed over a silica gel column to obtain Intermediate A10 with a purity of 93.50% and a yield of 63.60%.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Methylindoline, its application will become more common.
Reference:
Patent; Jiangsu March Optoelectric Technology Co., Ltd.; Xu Kai; Li Chong; Zhang Xiaoqing; Zhang Zhaochao; (49 pag.)CN107880031; (2018); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem