Synthetic Route of 446292-08-6, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 446292-08-6 as follows.
63.5 g of the compound 6 (0.15 mol) prepared in Example 4-2 was added to the reaction flask, ethanol (1000 mL), 80% hydrazine hydrate (0.825 mmol) was added dropwise at room temperature, then heated to reflux 2h, the reaction mixture was cooled to room temperature, and the solvent was distilled off under reduced pressure. 1000 mL of water was added and the mixture was extracted twice with dichloromethane (500 mL x 2). The dichloromethane phase was dried over anhydrous sodium sulfate and filtered through suction. The filtrate was evaporated to dryness to give a white solid which was dried in vacuo to give compound 7 (45.9 g); the yield was 95.4% and the purity was 99.7%.
According to the analysis of related databases, 446292-08-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Shandong Luoxin Pharmaceutical Group Stock Co. Ltd.; Hou, Junkai; Wang, Yuehui; Li, Hua; (12 pag.)CN105801572; (2016); A;,
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