Synthetic Route of 3891-07-4, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 3891-07-4, name is 2-(2-Hydroxyethyl)isoindoline-1,3-dione, This compound has unique chemical properties. The synthetic route is as follows.
To a cooled to -10 C. suspension of imidazole (16.3 g, 0.24 mol) and PPh3 (31.5 g, 0.12 mol) in dry CH2Cl2 (160 mL) I2 (30.5 g, 0.12 mol) was added in portions. After the addition the formed suspension was stirred for 30 min at room temperature followed by addition of P1 (15.3 g, 0.08 mol) in portions. The reaction mixture was stirred for 24 h, then aqueous Na2S2O3 was added. Organic layer was consequently washed with water, brine, and dried over Na2SO4. After evaporation yellow-green residue was obtained, which was chromatographed (CH2Cl2/hexanes 1:2) on silica gel. Recrystallization of the final product from hexanes/acetone yielded 20.9 g (87%) of white fibers.
The chemical industry reduces the impact on the environment during synthesis 2-(2-Hydroxyethyl)isoindoline-1,3-dione. I believe this compound will play a more active role in future production and life.
Reference:
Patent; Koltun, Dmitry; Zablocki, Jeff; Vasilevich, Natalya; Migulin, Vasily; US2009/253693; (2009); A1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem