These common heterocyclic compound, 3891-07-4, name is 2-(2-Hydroxyethyl)isoindoline-1,3-dione, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 3891-07-4
Compound 5 (28.29 g, 167.4 mmol) and DMA (65 mL) were added to compound 4 (20.00 g, 104.6 mmol) and stirred.After warming the reaction solution to 40 C., sodium tert-butoxide (15.09 g, 157.0 mmol) was slowly added.The reaction solution was stirred at 40 C for 3 hours and then cooled to 20 C.Acetic acid (3.14 g) and 10% saline (64 g) were added to the reaction solution,And extracted twice with ethyl acetate (60 mL). Water (144 mL) was added to the organic layer and the mixture was cooled to 0 C.The resulting pale yellowish white precipitate was collected by filtration.The resulting solid was washed with a mixture of methanol (5.4 g) and water (48.6 g)And dried to obtain Compound 6 (20.44 g, yield 78%) as a pale yellowish white solid.
The synthetic route of 2-(2-Hydroxyethyl)isoindoline-1,3-dione has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SHIONOGI & COMPANY LIMITED; SHIBAHARA, SETSUYA; FUKUI, NOBUAKI; MAKI, TOSHIKATSU; (38 pag.)JP6212678; (2017); B1;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem