Related Products of 6872-06-6, These common heterocyclic compound, 6872-06-6, name is 2-Methylindoline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
2-methylindoline (3.26 g, 24.5 mmol) and hexane (0.536 M, 45.7 ml) were placed in a 100 ml Schlenk flask. At -20 C, n-BuLi (1.1 eq, 10.8 ml) was added and allowed to stand at room temperature overnight. Filtered through glass frit (G4) and vacuum dried to obtain phosphine-amine lithium. The phosphine-amine lithium (3.37 g, 24.2 mmol) was added to diethyl ether (0.423 M, 57.3 ml) in a 250 ml Schlenk flask and CO2 bubbling was added at -78 C for 1 hour. THF (1.1 eq, 2.16 ml) and t-BuLi (1.1 eq, 15.7 ml) were added at -20 C and kept at this temperature for 2 hours. IPr2PCl (0.85 eq, 3.14 g) and diethyl ether (0.359 M, 57.3 ml) were added at the same temperature and maintained at the same temperature for 1 hour. After slowly reacting at room temperature overnight, 50 ml of distilled water was added at 0 C, and the mixture was stirred at room temperature for 30 minutes. Work-up with diethyl ether, drying over MgSO4, and then red oil was obtained in 2.23 g, 37% yield via hexane, diethyl ether 50: 1 column
The synthetic route of 6872-06-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; LG CHEM, LTD.; JANG, Jae Kwon; KIM, Seul Ki; PARK, In Sung; LEE, Eun Jung; LEE, Choong Hoon; HAN, Ki Won; HAN, Hyo Jung; (20 pag.)KR2017/68330; (2017); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem