A new synthetic route of 59-48-3

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 59-48-3, name is Indolin-2-one, A new synthetic method of this compound is introduced below., Recommanded Product: 59-48-3

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 59-48-3, name is Indolin-2-one, A new synthetic method of this compound is introduced below., Recommanded Product: 59-48-3

5-Iodo-2-oxindole 2-Oxindole (82.9 g) was suspended in 630 ML of acetic acid with mechanical stirring and the mixture cooled to 10 C. in an ice water bath.. solid N-iodosuccinimide (175 g) was added in portions over 10 minutes.. After the addition was complete the mixture was stirred for 1.0 hour at 10 C. The suspended solid which had always present became very thick at this time.. The solid was collected by vacuum filtration, washed with 100 ML of 50 % acetic acid in water and then with 200 ML of water and sucked dry for 20 minutes in the funnel.. The product was dried under vacuum to give 93.5 g (36%) of 5-iodo-2-oxindole containing about 5% 2-oxindole by proton NMR.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Sugen, Inc.; US6350754; (2002); B2;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem