In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 6941-75-9, name is 5-Bromoisoindoline-1,3-dione belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below. Quality Control of 5-Bromoisoindoline-1,3-dione
To a solution of hydroxyproline tripeptide precursor (200 mgs, 0.359mmol) in 4 mL of DMF at room temperature was added 4-bromophthalimide(97 mgs, 0.430 mmol) and triphenyl phosphine (206 mgs, 0.789 mmol).Sonicate until dissolved and add DIAD (152 uL, 0.789 mmol). Stir at roomtemperature overnight. Remove solvent under reduced pressure and extractwith ethyl acetate and water. ‘Separate the layers and dry over MgSCu, filterand strip. Purify using silica gel chromatography eluting (10 -100% ethylacetate in hexane). Further purify on reverse phase HPLC (ACN/Water) toafford 102 as a white solid (98 mgs, 36%). 1H NMR (300 MHz, CDCls): 5 7.95(s, 1H), 7.88 (d, J=7.9 Hz, 1H), 7.71 (d, J= 7.7 Hz, 1H), 7.65 (s, 1H), 7.43 (s, 1H),6.03 (m, 1H), 5.37 (d, J= 15.5 1H), 5.31-5.07 (bs, 5H), 4.91 (m, 1H), 4.77 (m, 1H),4.23-4.03 (bs, 7H), 3.81 (t, J= 7.9Hz, 1H), 2.75 (m, 2H), 2.01 (m, 1H), 1.68-1,50(bs, 8H), 1.30 (q, J= 7.0 Hz, 6H), 1.10 (s, 1H), 0.99 (s, 9H). 31P NMR (300 MHz,CDCls): 8 22.92 (s, IP), 22.75 (s, IP). LC/MS: 766 (M++ 1).
The synthetic route of 6941-75-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; GILEAD SCIENCES, INC.; WO2006/20276; (2006); A2;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem