5332-26-3, name is 2-(Bromomethyl)isoindoline-1,3-dione, belongs to indolines-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 5332-26-3
A solution of n-butyllithium in THF (1.8 ml, 2.5 M, 4.5mmol) was added in to a cooled mixture of HMDS (608 mg, 4.56 mmol) in THF (20 ml) dropwise over 20 min with stirring. The mixture was stirred for 30 min before benzyl 2-(4- ((cyclopropylmethyl)sulfonyl)phenyl)acetate (1.3 g, 3.8 mmol) in THF (5 ml) was added through a syringe dropwise over 10 min. Stirred for another 30 min at -78 followed by the addition of 2-(bromomethyl)isoindoline-1,3-dione (912 mg, 3.8 mmol) in THF (5 ml) was added through a syringe over 10 min. The mixture was stirred at -78 and allowed to reach to room temperature overnight. The mixture was treated with methanol carefully and the solvents were evaporated. The product was purified by flash chromatography to affod the product as a White solid 1.4 g (74% yield). MS (+) ES: 504 (M+H)+.
The synthetic route of 5332-26-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ETERNITY BIOSCIENCE INC.; YAN, Yinfa; ZHANG, Minsheng; LIU, Dong; ZHANG, Fengqi; LIU, Suxing; ZHANG, Rumin; HE, Feng; TAO, Weikang; (211 pag.)WO2019/213470; (2019); A1;,
Indoline – Wikipedia,
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