In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 65826-95-1, name is 5-Methylindoline belongs to indolines-derivatives compound, it is a common compound, a new synthetic route is introduced below. category: indolines-derivatives
(1) 1.33 g of 5-methylindoline and 2-chloropyridine were added to a 50 mL round bottom flask, the ratio of the amount of the substance was 1: 1.5; (2) Stir directly in the air and mix evenly at room temperature.Then heated at 80 C, after 45 min, the system solidified, stopped the reaction, and cooled to room temperature; (3) Add 50 mL of saturated NaHCO3 solution to the system to dissolve the solid.Further, 50 mL of ethyl acetate solution was added, shaken, and liquid-separated, and the aqueous phase was extracted three times with ethyl acetate, 30 mL each time, and the organic phase was combined and concentrated by a rotary evaporator; (4) The concentrate was dissolved in 20 mL of ethanol, refluxed at 80 C for 15 min, cooled, and a pale yellow solid was separated, filtered, rinsed with water and dried in vacuo to give the desired product.
The synthetic route of 65826-95-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Northwest University; Jiao Linyu; Zhang Ze; Yin Xiaomei; Hong Qian; Ning Zihui; Ma Xiaoxun; Li Zhuo; Sun Ming; (11 pag.)CN109265439; (2019); A;,
Indoline – Wikipedia,
Indoline | C8H9N – PubChem